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The aim of the issue is to describe and explain the importance of the chemokine system in hematology. As described in the introduction the chemokine system is probably important for many aspects of normal as well as malignant hematopoiesis. A major focus is the development and treatment of hematologic malignancies, including the immunobiology of stem cell transplantation.” The present reviews illustrate that chemokines can be involved in leukemogenesis. The chemokine system is also important both for the crosstalk between malignant cells and their neighbouring nonmalignant stromal cells (including endothelial cells) as well as for immunoregulation in patients treated with allogeneic stem cell transplantation. Thus, chemokines are important both for the pathogenesis and treatment of hematological diseases.

Blood -- Diseases -- Immunological aspects. --- Blood -- Diseases. --- Chemokines. --- Hematology, Experimental. --- Hematology. --- Chemokines --- Hematology, Experimental --- Blood --- Antigens, CD --- Cell Transplantation --- Cytokines --- Inflammation Mediators --- Chemotaxis --- Chemotactic Factors --- Biological Science Disciplines --- Receptors, G-Protein-Coupled --- Receptors, Cytokine --- Leukemia, Myeloid --- Immune System Diseases --- Chemotaxis, Leukocyte --- Stem Cell Transplantation --- Receptors, Chemokine --- Graft vs Host Disease --- Leukemia, Myeloid, Acute --- Physiology --- Leukemia --- Natural Science Disciplines --- Biological Factors --- Intercellular Signaling Peptides and Proteins --- Antigens, Differentiation --- Diseases --- Transplantation --- Receptors, Immunologic --- Cell Movement --- Receptors, Cell Surface --- Biological Markers --- Peptides --- Neoplasms by Histologic Type --- Proteins --- Disciplines and Occupations --- Chemicals and Drugs --- Surgical Procedures, Operative --- Antigens, Surface --- Membrane Proteins --- Cell Physiological Processes --- Amino Acids, Peptides, and Proteins --- Neoplasms --- Antigens --- Cell Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Phenomena and Processes --- Medicine --- Biology --- Oncology --- Microbiology & Immunology --- Health & Biological Sciences --- Immunological aspects. --- Chemotactic cytokines --- Inflammatory peptides --- Intercrines --- Experimental hematology --- Haematology --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Internal medicine --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Inflammation --- Medicine, Experimental --- Physiology, Experimental --- Body fluids --- Fear of blood --- Mediators --- Oncology. --- Tumors